Estimation of virus-mediated cell fusion rate of SARS-CoV-2Article Published on 2022-10-012023-07-10 Journal: Virology [Category] COVID19(2023년), [키워드] ACE2 receptor furin Fusion rate Mathematical modelling Spike protein syncytia formation TMPRSS2. [DOI] 10.1016/j.virol.2022.08.016 PMC 바로가기
Evolution of the SARS-CoV-2 omicron variants BA.1 to BA.5: Implications for immune escape and transmissionArticle Published on 2022-09-012022-11-15 Journal: Reviews in Medical Virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] administration antibody approved Booster vaccine Combination Community consequence current Delta delta variant diagnosed dominant dominant variant Efficacy Evolution FDA higher infectivity human lung tissue immune Immune escape immune evasion Immunity immunocompromised individual IMPROVE Infection less monoclonal monoclonal antibodies Mutation mutations neutralising omicron Omicron variant Omicron. other variant Protein public health recombination event reduced reduction reported SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants several variants severity Sotrovimab spike Spread syncytia formation the SARS-CoV-2 therapeutic use Transmission Vaccine variant variants of SARS-CoV-2 Wuhan-Hu-1 zoonotic [DOI] 10.1002/rmv.2381 PMC 바로가기
A trifunctional peptide broadly inhibits SARS-CoV-2 Delta and Omicron variants in hamsters Research Published on 2022-06-302022-10-05 Journal: Cell Discovery [Category] 치료제, [키워드] Antiviral antiviral activity block cellular Clustering concern COVID-19 cases Delta delta variant Endocytic pathway hamster hamsters in vitro inhibit inhibiting lung viral titer Lungs membrane fusion omicron peptide Prevent reduce reduction required SARS-CoV-2 SARS-CoV-2 variant significantly syncytia formation the SARS-CoV-2 trifunctional variant viral entry virion virus VOCs [DOI] 10.1038/s41421-022-00428-9 [Article Type] Research
ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusionADAM10 및 ADAM17은 SARS-CoV-2 세포 진입 및 스파이크 단백질 매개 폐 세포 융합을 촉진합니다Article Published on 2022-06-072022-09-11 Journal: EMBO Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] A549 ADAM10 ADAM17 Alpha antiviral drug apratastat Beta causative agent Cell Cell fusion cleave contribute contributing to COVID-19 COVID-19 pathogenesis COVID-19 pathology DPC-333 ectodomain ectodomain shedding expressed facilitator hallmark Host host cell host cell factor host cell factors human lung human lung cell identify impair in vitro Infection inhibitor lung cell omicron Pathogenesis pathology priming promote protease Proteases reduce required SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 variants Spike protein syncytia formation syncytia formation. target the SARS-CoV-2 TMPRSS2 TMPRSS2 protease variants of concern viral entry [DOI] 10.15252/embr.202154305 PMC 바로가기 [Article Type] Article
Impairment of SARS-CoV-2 spike glycoprotein maturation and fusion activity by nitazoxanide: an effect independent of spike variants emergenceOriginal Article Published on 2022-04-072023-07-01 Journal: Cellular and Molecular Life Sciences [Category] COVID19(2023년), SARS, [키워드] broad-spectrum antiviral COVID-19 nitazoxanide SARS-CoV-2 spike SARS-CoV-2 variants syncytia formation [DOI] 10.1007/s00018-022-04246-w PMC 바로가기 [Article Type] Original Article
The spike protein of SARS-CoV-2 induces heme oxygenase-1: Pathophysiologic implicationsSARS-CoV-2의 스파이크 단백질은 헴 옥시게나제-1을 유도합니다: 병태생리학적 의미Article Published on 2022-03-012022-09-12 Journal: Biochimica et biophysica acta. Molecular basis of [Category] MERS, SARS, 진단, [키워드] ACE2 Acute kidney injury adaptive AKI angiotensin-converting enzyme 2 assessment caused Cell cell lines cellular clinically COVID-19 COVID-19 patient Effect enzyme examined expression HEK293 heme Heme oxygenase-1 ICAM1 implication induce inducer kidney Kidney injury major organ MCP-1 nephrotoxic outcome overexpressing Plasmid Protective protein expression provide quercetin reduced response SARS-CoV-2 SARS-CoV-2 spike signaling pathway spike Spike protein Spike protein expression syncytia formation syncytia. TNF-α transfected with transfecting upregulate upregulated Urine Vero E6 cell viral spike protein virus was performed [DOI] 10.1016/j.bbadis.2021.166322 PMC 바로가기 [Article Type] Article
Loss of Detection of sgN Precedes Viral Abridged Replication in COVID-19-Affected Patients—A Target for SARS-CoV-2 PropagationCOVID-19에 감염된 환자에서 sgN 검출 손실이 바이러스 요약 복제보다 먼저 발생 - SARS-CoV-2 전파의 표적Article Published on 2022-02-092022-09-10 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 치료기술, 치료법, 치료제, [키워드] 2′-O-methyl antisense RNA ACE2 addition Alpha Analysis B.1.1.7 correlation correlations Cq value Cq values detection Disease progression Early detection evaluated focus future therapeutic HEK-293T cell HEK-293T cells Hospitalized human cell human cells impair in vitro study indicated Infection Loss marker ORF1ab overexpressing Patient patient condition positive sample Propagation Prophylactic public health qPCR qPCR methods RNA RNA transcript RNase P SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 virus SARS-CoV-2 virus particles sequence sgE sgN shown surrogate markers Swab syncytia formation target the SARS-CoV-2 virus variant Viral viral loads viral replication virus replication VoC [DOI] 10.3390/ijms23041941 PMC 바로가기 [Article Type] Article
A new screening system for entry inhibitors based on cell-to-cell transmitted syncytia formation mediated by self-propagating hybrid VEEV-SARS-CoV-2 repliconCoronaviruses Published on 2022-02-042022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, COVID19(2023년), SARS, [키워드] addition antiserum Antiviral agents biosafety BSL-2 laboratory BSL-3 facility Cell COVID-19 Critical dose-dependent Entry inhibitor entry inhibitors events Evidence GFP Increasing inhibitor inhibitors live SARS-CoV-2 pathway performed positive Protein reporter vector responsible SARS-CoV-2 seeking Severe case shown spike Syncytia syncytia formation syncytium formation the S protein Transmission transmission rate transmitted Treatment VEEV Venezuelan equine encephalitis viral spike virus [DOI] 10.1080/22221751.2022.2030198 PMC 바로가기 [Article Type] Coronaviruses
Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia formation계산 우선 순위 화 약물은 SARS-COV-2 감염 및 Syncytia 형성을 억제합니다Case Study Published on 2022-01-272022-09-10 Journal: Briefings in Bioinformatics [Category] 변종, 신약개발, 치료제, [키워드] 7-hydroxystaurosporine anti-inflammatory strategy Antiviral effect bafetinib candidate candidate drug candidate drugs compounds computational approach computational method Computational methods COVID-19 COVID-19 pandemic data-driven de novo delta variant drug drug design drug repositioning drugs effective effective drugs help human cell human cells in vitro Infection information inhibit inhibit SARS-CoV-2 kinase inhibitors list pharmacological SARS-CoV-2 selected subset Syncytia syncytia formation synergistic Treatment treatment of COVID-19 vaccination viral-induced Virtual screening [DOI] 10.1093/bib/bbab507 PMC 바로가기 [Article Type] Case Study
Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmissionArticle Published on 2022-01-212023-06-15 Journal: Cell Host & Microbe [Category] MERS, SARS, [키워드] fusion Gamma H655Y mutation omicron SARS-CoV-2 spike cleavage syncytia formation variants of concern [DOI] 10.1016/j.chom.2022.01.006 PMC 바로가기 [Article Type] Article